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ZitatTom Wagner: PulseAudio is mostly designed to have applications receive audio input from one single input device and/or send audio to a single output device, which makes it difficult to adapt to more complicated use-cases.
Contrary to PulseAudio, PipeWire runs a full media graph. This means that audio and other kinds of media can be freely routed between any number of devices and even to other applications at the same time.
For example, you could route the audio output of your music streaming software to your speakers as well as your voice-chat software to listen with others, while routing the audio and video of a game to a recording software to make a recording without the music in it.
Helvum is a GUI to do exactly this: create and delete connections between devices and/or programs to route data through the system in exactly the way you want it.